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What tests are included in the repeat miscarriage study?

By Guillermo Quea Campos M.D. (gynecologist).
Last Update: 04/05/2022

Repeat Abortion (RA) is defined as the loss of two or more pregnancies before 20 weeks, whether consecutive or not. Although there is no consensus on when to start the study, it is reasonable to individualize each case.

With this, and to know what tests the RA study includes, we must know the etiology of this pathology, which is divided into 3 large groups:

Proven causes
genetic factors and antiphospholipid syndrome.
Unproven but probable causes
uterine anatomical alterations and thrombophilias.
Unproven causes
endocrine factors, infections and autoimmune causes not related to antiphospholipid syndrome.

In accordance with this, and in order to rule out proven or probable causes, we will request the following tests:

Antiphospholipid syndrome
Anticardiolipin antibodies (IgG and IgM); Lupus Anticoagulant Antibodies (IgG and IgM); Anti ß2 glycoprotein (IgG and IgM).
Genetics
karyotype in both members of the couple; possibility of a Sperm FISH or Preimplantation Genetic Diagnosis (PGD) in the embryos.
Thrombophilias
Factor V Leiden mutation, Prothrombin 20210A Gene Mutation, Metallotetrahydrofolatoreductase (MTHFR) Gene Mutation; Homocysteine ​​levels
Anatomical
transvaginal ultrasound or hysteroscopy.
Imagen: What tests are done in cases of repeated miscarriages?
 Guillermo Quea Campos
Guillermo Quea Campos
M.D.
Gynecologist
Guillermo Quea, MD has a degree in Medicine and Surgery from the University of San Martin de Porres. He also has a Master's Degree in Human Reproduction from the Universidad Rey Juan Carlos and another in Public Health and Preventive Medicine from the Universidad del País Vasco.
Member number: 282860962
Gynecologist. Guillermo Quea, MD has a degree in Medicine and Surgery from the University of San Martin de Porres. He also has a Master's Degree in Human Reproduction from the Universidad Rey Juan Carlos and another in Public Health and Preventive Medicine from the Universidad del País Vasco. Member number: 282860962.