Causes of Kallmann Syndrome (KS)

Kallmann Syndrome (KS) is caused by a lack of GnRH hormone (gonadotropin-releasing hormone). The origin of this disorder can be found during the embryonic development of the affected individual—the cells of the hypothalamus, responsible for the production of GnRH, did not migrate adequately from the olfactory epithelium to the pituitary gland, where they develop their function.

Lacking GnRH leads to an inadequate secretion of sex hormones, which affects the sexual development of the males and females affected by this disease.