Oligohydramnios: causes, diagnosis and treatment in pregnancy

By (gynecologist), (embryologist) and (psychologist).
Last Update: 01/26/2022

Amniotic fluid is the fluid that surrounds the fetus during gestation. It is located inside the amniotic sac and has the function of protecting the fetus throughout its development, from the beginning of pregnancy until the birth of the baby.

An abnormal amount of amniotic fluid is indicative of fetal abnormalities or problems in the mother that may jeopardize the pregnancy. Therefore, it is important to measure the volume of amniotic fluid in ultrasound scans, especially in the last trimester.

A small amount of amniotic fluid is referred to as oligohydramnios while an excessive amount of amniotic fluid is referred to as polyhydramnios.

Definition of oligohydramnios

The term oligohydramnios refers to the small amount of amniotic fluid in pregnancy. This disorder affects less than 10% of pregnant women, although only about 5% are diagnosed.

Oligohydramnios usually occurs in the last trimester, especially if the pregnant woman is past her due date, although it can also occur at any other time during pregnancy.

In general, the consequences of oligohydramnios are more severe if it appears in the first two trimesters of gestation than in the third trimester. Despite this, most pregnancies with oligohydramnios manage to develop normally and result in the birth of healthy babies.

The amount of amniotic fluid varies throughout gestation. On average, the amniotic sac contains about 30 ml of fluid at 10 weeks, 100 ml at week 14, 200 ml at week 16, and reaches its maximum at week 34, with about 800 ml of amniotic fluid.

After 36 weeks, the amount of amniotic fluid gradually decreases to 600 ml at the end of pregnancy, but it should never disappear.

How is amniotic fluid measured?

The amount of amniotic fluid can be measured with an ultrasound scan using the so-called Phelan's method or, in other words, by calculating the amniotic fluid index (AFI).

This method consists of dividing the uterine cavity into four quadrants and then measuring the diameters of the maximum amniotic fluid-free lacunae in each quadrant.

The AFI is obtained by adding these 4 measurements. The normal AFI value should be between 8-24 cm to consider that the amniotic fluid volume is correct.

An AFI<8 or an amniotic fluid volume of less than 500 ml between 32 and 36 weeks of gestation are indicative of oligohydramnios.

Causes

It is not always possible to find out for sure what the exact cause of oligohydramnios is. However, the main reasons for decreased amniotic fluid are as follows:

Post-term pregnancy
when the pregnancy is about two weeks beyond the approximate due date.
Premature rupture of membranes (PROM)
the amniotic sac ruptures before delivery and some of the amniotic fluid may escape. The woman may notice these losses in her previous clothes.
Alterations in the placenta
such as placental abruption, which can prevent sufficient blood and nutrients from reaching the fetus and stop the fetus from producing urine.
Maternal problems
preeclampsia, chronic hypertension, dehydration, diabetes, lupus, etc.
Multiple pregnancy
the occurrence of intergemellar transfusion syndrome, in which one of the twins has too little amniotic fluid while the other generates too much.
Fetal alterations
congenital malformations affecting the kidneys and urinary tract, fetal growth restriction, fetal death, etc.
Medications
drugs containing angiotensin-converting enzyme inhibitors, such as captopril to treat hypertension, can cause oligohydramnios.

Symptoms and complications

Insufficient amniotic fluid can cause more or less serious problems for the baby depending on the stage of pregnancy.

In most cases, oligohydramnios does not cause any symptoms in the woman and, therefore, will only be diagnosed in a control ultrasound. The only possible symptom is loss of amniotic fluid if there is a rupture of the membrane.

We will now discuss the possible risks of oligohydramnios in each trimester of pregnancy:

First trimester
lack of amniotic fluid in early pregnancy can have fatal consequences since this is when all the organs of the future baby are formed. Thus, oligohydramnios can lead to malformations of the lungs, arms, or legs. It also poses a risk of miscarriage, premature delivery or intrauterine fetal death.
Second trimester
during this period, oligohydramnios affects fetal growth and may also impede the proper formation and maturation of the lungs.
Third trimester
although complications are minor, the lack of amniotic fluid in late pregnancy increases the risk of umbilical cord compression, which affects the baby's oxygenation and heart rate. Oligohydramnios also increases the risk of complications during labor, leading to the need for a cesarean section.

Treatment

The treatment of oligohydramnios consists of a more exhaustive control of the pregnancy. The woman will have to have several ultrasounds to make sure that the fetus is growing at the right rate.

Other indications to treat the lack of amniotic fluid are to drink a lot, control the baby's kicking and activity, partial or complete rest, etc. This will depend on how far along the pregnancy is and whether there are other associated disorders.

If the woman is at an advanced stage of gestation, it is very likely that labor will be induced, especially if fetal distress is confirmed.

A novel technique that can help maintain amniotic fluid levels during labor is amnio-infusion. It consists of inserting a catheter through the cervix and constantly pumping a saline solution into the amniotic sac. This reduces the risk of umbilical cord compression and increases the likelihood of a natural delivery.

FAQs from users

What recommendations should a woman with oligohydramnios follow?

By Rut Gómez de Segura M.D. (gynecologist).

Oligohydramnios occurs when the volume of amniotic fluid is decreased during gestation. The diagnosis is ultrasound, measuring the amount of amniotic fluid by ultrasound.
We can divide the causes of Oligohydramnios into three main groups:

  • Fetal causes: restricted intrauterine growth (RIC), chronologically prolonged gestation (CPG), fetal infection or alterations of the fetal urinary tract.
  • Placental-membrane causes: premature rupture of membranes (PROM) accounts for most cases.
  • Maternal causes: maternal medication.

Depending on the cause of Oligohydramnios and the time of pregnancy, your obstetrician will give you recommendations.

What is the reason for the low amount of amniotic fluid?

By Zaira Salvador B.Sc., M.Sc. (embryologist).

There are several causes of amniotic fluid shortage in pregnancy, such as rupture of the membranes, placental abruption, hypertension, fetal malformations, prolonged pregnancy, etc.

How can oligohydramnios be classified?

By Zaira Salvador B.Sc., M.Sc. (embryologist).

The classification of oligohydramnios based on its severity is as follows:

Mild
AFI between 6 and 7.
Moderate
API between 4 and 5.
Severe
ILA<3.

It should be noted that there are variations in this classification depending on the specialist. In addition, it is also necessary to assess other parameters, such as blood pressure, to make an accurate diagnosis of oligohydramnios.

What are the consequences of moderate or severe oligohydramnios?

By Zaira Salvador B.Sc., M.Sc. (embryologist).

The lack of amniotic fluid for a prolonged period of time can affect the organogenesis and growth of the fetus, especially the maturation of the lungs, leading to pulmonary hypoplasia.

At the time of delivery, oligohydramnios can also lead to complications such as fetal distress or meconium aspiration syndrome (MAS), leading to emergency cesarean section.

One of the causes of oligohydramnios is the rupture of the amniotic sac before delivery. If you want to know all the details about this, we recommend you to read the following article: How do I know if I am losing amniotic fluid in pregnancy?

Another alteration in the amount of amniotic fluid is polyhydramnios, that is, excess amniotic fluid. If you want to know what this alteration consists of, you can continue reading here: What is polyhydramnios?

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References

Authors and contributors

 Rut Gómez de Segura
Rut Gómez de Segura
M.D.
Gynecologist
Graduation in Medicine and Surgery from the University of Alcalá de Henares. Specialization in Obstetrics and Gynecology at the Hospital Costa del Sol in Marbella. Dr Rut Gómez de Segura currently works as medical director in the fertility center ProcreaTec in Madrid. More information about Rut Gómez de Segura
Licence number: 28/2908776
 Zaira Salvador
Zaira Salvador
B.Sc., M.Sc.
Embryologist
Bachelor's Degree in Biotechnology from the Technical University of Valencia (UPV). Biotechnology Degree from the National University of Ireland en Galway (NUIG) and embryologist specializing in Assisted Reproduction, with a Master's Degree in Biotechnology of Human Reproduction from the University of Valencia (UV) and the Valencian Infertility Institute (IVI) More information about Zaira Salvador
License: 3185-CV
Adapted into english by:
 Cristina  Algarra Goosman
Cristina Algarra Goosman
B.Sc., M.Sc.
Psychologist
Graduated in Psychology by the University of Valencia (UV) and specialized in Clinical Psychology by the European University Center and specific training in Infertility: Legal, Medical and Psychosocial Aspects by University of Valencia (UV) and ADEIT.
More information about Cristina Algarra Goosman
Member number: CV16874

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